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KMID : 0811720020060000168
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Korean Journal of Physiology & Pharmacology
2002 Volume.6 No. 0 p.168 ~ p.0
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Mechanism of Diet-induced Insulin Resistance of Skeletal Muscles in Rats
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Jang Eung-Chan
Kim Jong-Yeon
Lee Suck-Kang
Jeon Mu-Ryun
Park So-Young
Kim Yong-Woon
Doh Kyung-Oh
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Abstract
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1. Dietary composition in carbohydrates diet on muscle insulin resistance: High sucrose diet depressed insulin-stimulated glucose transport compared with chow diet, but glucose transport rate was not different from starch diet. HF diet induced decrease in insulin-stimulated glucose transport, but sucrose did not change the level of muscle insulin resistance of skeletal muscles. Visceral fat accumulation was not different between high starch and high sucrose groups. 2. Dietary composition in fat diet on muscle insulin resistance: HF diet caused markedly decrease in insulin-stimulated glucose transport of skeletal muscles, and fish oil improved or prevented the decrease in insulin-stimulated glucose transport of skeletal muscles partially, but linseed oil did not significantly. However it seemed dietary fat composition in fat diet can alter the degree of insulin resistance of skeletal muscles. Visceral fat accumulation was altered by dietary composition change in fat diet. 3. Related factors causing muscle insulin resistance induced by high carbohydrates or high fat diets: % visceral fat pad mass to body weight in HT, HS, HFHT, and HFHS groups that developed muscle insulin resistance were much higher compared with chow diet group. Plasma insulin concentrations in HT, HS, HFHT, and HFHS groups that developed muscle insulin resistance were much higher compared with chow diet group. Plasma glucose concentrations among groups were not different significantly. Plasma triglyceride concentrations in HT, HS, HFHT, and HFHS groups that developed muscle insulin-resistance were much higher compared with chow diet rats. % Visceral fat pad mass to body weight in HF group that developed muscle insulin resistance were much higher compared with chow diet rats, and FO and LO decreased it significantly compared with chow diet group. Plasma glucose concentrations among groups were not different significantly. Plasma insulin concentrations in HF group was increased compared with chow diet group, and FO decreased it significantly. Plasma triglyceride concentrations in HF group was increased compared with chow diet group, and FO decreased it significantly.
Source: Korean Journal of Physiology & Pharmacology.2002 Oct;6(Suppl II):S113-S113
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KEYWORD
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insulin resistance, glucose transport, high sucrose, high fat diet
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